0049 αB crystallin as a novel marker of lymph node metastasis in breast cancer
نویسندگان
چکیده
منابع مشابه
αB-crystallin: a novel regulator of breast cancer metastasis to the brain.
PURPOSE Basal-like breast tumors are typically (ER/PR/HER2) triple-negative and are associated with a high incidence of brain metastases and poor clinical outcomes. The molecular chaperone αB-crystallin is predominantly expressed in triple-negative breast cancer (TNBC) and contributes to an aggressive tumor phenotype in preclinical models. We investigated the potential role of αB-crystallin in ...
متن کاملCCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer.
PURPOSE The chemokine receptors CCR7 and CXCR4 have been shown to play an important role in cancer metastasis. We therefore studied the differential expression of CCR7 and CXCR4, along with that of the biomarker HER2-neu, to evaluate whether these biomarkers could predict axillary lymph node metastasis in breast cancer. EXPERIMENTAL DESIGN Biomarker expression levels were evaluated using para...
متن کاملPotential role of hsa_circ_0003098 circular RNA in breast cancer and its association with demographic factors and lymph node metastasis
Background and Objectives: A growing amount of evidence has revealed that circular RNAs (circRNAs), covalently closed single-stranded non-coding RNAs (ncRNAs), play significant roles in initiation and progression of breast cancer (BC) through different mechanisms. This study aims to investigate the hsa_circ_0003098 expression and its potential roles in BC, as well as the circRNA/miRNA/mRNA cro...
متن کاملBreast Axillary Lymph Node Metastasis
1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC 20007, USA 2Clinical Breast Care Project, 620 Seventh Street, Windber, PA 15963, USA 3Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany 4Department of Pathology, University of Milan School o...
متن کاملLymph node shape in computed tomography imaging as a predictor for axillary lymph node metastasis in patients with breast cancer
The aim of the present study was to evaluate whether preoperative computed tomography (CT) is a useful modality for the diagnosis of axillary lymph node metastasis. The axillary lymph node status was examined in patients with primary breast cancer who had undergone surgery. In total, 75 patients were analyzed with preoperative contrast CT images, following which the patients underwent an intrao...
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ژورنال
عنوان ژورنال: The Breast
سال: 2009
ISSN: 0960-9776
DOI: 10.1016/s0960-9776(09)70094-3